Download the fantastic book titled Blood Brain Barrier in Drug Discovery written by Li Di, available in its entirety in both PDF and EPUB formats for online reading. This page includes a concise summary, a preview of the book cover, and detailed information about "Blood Brain Barrier in Drug Discovery", which was released on 02 February 2015. We suggest perusing the summary before initiating your download. This book is a top selection for enthusiasts of the Medical genre.
Summary of Blood Brain Barrier in Drug Discovery by Li Di PDF
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Detail About Blood Brain Barrier in Drug Discovery PDF
- Author : Li Di
- Publisher : John Wiley & Sons
- Genre : Medical
- Total Pages : 604 pages
- ISBN : 1118788354
- Release Date : 02 February 2015
- PDF File Size : 17,8 Mb
- Language : English
- Rating : 4/5 from 21 reviews
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