Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry Book [PDF] Download

Download the fantastic book titled Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry written by Tim Wezeman, available in its entirety in both PDF and EPUB formats for online reading. This page includes a concise summary, a preview of the book cover, and detailed information about "Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry", which was released on 31 December 2016. We suggest perusing the summary before initiating your download. This book is a top selection for enthusiasts of the Science genre.

Summary of Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry by Tim Wezeman PDF

Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and pyrazoles. The synthesis of a wide array of sulfonyl ynamides can be realized via copper-catalyzed amidative cross-couplings or by elimination of dichloroenamide precursors. Additionally the use of Sonogashira chemistry to further diversify terminal ynamides and the synthesis of solid-supported ynamides was investigated. Electrophilically-activated amides can be reacted with sulfonyl ynamides in order to access highly functionalized 4-aminoquinolines. The straightforward amide activation procedure with triflic anhydride and 2-chloropyridine was found to tolerate a wide range of substrates, which allowed for the development of a library of 4-aminoquinolines with ease. Moreover, 4-aminopyrazoles can be prepared by reacting terminal sulfonyl ynamides with sydnones under copper catalysis. However, as the copper catalysts were also found to promote the degradation of the ynamides, a copper-free strain-promoted alternative was developed. An in situ prepared 3-azacyclohexyne was found to tolerate a wide array of C-4 substituted sydnones, producing a mixture of both the 3,4- and 4,3-fused pyrazoles in good yields. Additional investigations into heterocyclic methodology led to the development of highly sophisticated, non-symmetrical and axially-chiral dibenzo-1,3-diazepines, -oxazepines and -thiazepines from simple, commercially available anilines. The anilines were coupled to their corresponding reaction partners via a chloromethyl intermediate and the 7-membered ring was subsequently formed using direct arylation.


Detail About Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry PDF

  • Author : Tim Wezeman
  • Publisher : Logos Verlag Berlin GmbH
  • Genre : Science
  • Total Pages : 253 pages
  • ISBN : 383254397X
  • PDF File Size : 39,7 Mb
  • Language : English
  • Rating : 4/5 from 21 reviews

Clicking on the GET BOOK button will initiate the downloading process of Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry by Tim Wezeman. This book is available in ePub and PDF format with a single click unlimited downloads.

GET BOOK

Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry

Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry
  • Publisher : Logos Verlag Berlin GmbH
  • File Size : 41,8 Mb
  • Release Date : 31 December 2016
GET BOOK

Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry
  • Publisher : Elsevier
  • File Size : 27,8 Mb
  • Release Date : 16 June 2009
GET BOOK

This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds
  • Publisher : Elsevier
  • File Size : 23,6 Mb
  • Release Date : 04 November 2016
GET BOOK

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry

Catalytic Cascade Reactions

Catalytic Cascade Reactions
  • Publisher : John Wiley & Sons
  • File Size : 36,6 Mb
  • Release Date : 11 November 2013
GET BOOK

Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research

Bio-Based Solvents

Bio-Based Solvents
  • Publisher : John Wiley & Sons
  • File Size : 51,9 Mb
  • Release Date : 29 June 2017
GET BOOK

A multidisciplinary overview of bio-derived solvent applications, life cycle analysis, and strategies required for industrial commercialization This book provides the first and only comprehensive review of the state-of-the-science in bio-derived

Defining Moments Study Guide

Defining Moments Study Guide
  • Publisher : Multnomah
  • File Size : 53,8 Mb
  • Release Date : 11 December 2004
GET BOOK

Face the Truth Life is full of defining moments. Like landmarks on a road map, these moments mark key points along your life’s journey. A defining moment happens when

Organic Synthesis in Water

Organic Synthesis in Water
  • Publisher : Springer Science & Business Media
  • File Size : 31,8 Mb
  • Release Date : 06 December 2012
GET BOOK

The use of water as a medium for promoting organic reactions has been rather neglected in the development of organic synthesis, despite the fact that it is the solvent in

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
  • Publisher : John Wiley & Sons
  • File Size : 30,9 Mb
  • Release Date : 26 April 2013
GET BOOK

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why

The Chemistry of Heterocycles

The Chemistry of Heterocycles
  • Publisher : Elsevier
  • File Size : 32,7 Mb
  • Release Date : 05 June 2019
GET BOOK

Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of

Comprehensive Organic Reactions in Aqueous Media

Comprehensive Organic Reactions in Aqueous Media
  • Publisher : John Wiley & Sons
  • File Size : 28,7 Mb
  • Release Date : 04 June 2007
GET BOOK

An extensive update of the classic reference on organic reactions in water Published almost a decade ago, the first edition has served as the guide for research in this burgeoning