Download the fantastic book titled Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry written by Tim Wezeman, available in its entirety in both PDF and EPUB formats for online reading. This page includes a concise summary, a preview of the book cover, and detailed information about "Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry", which was released on 31 December 2016. We suggest perusing the summary before initiating your download. This book is a top selection for enthusiasts of the Science genre.
Summary of Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry by Tim Wezeman PDF
Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and pyrazoles. The synthesis of a wide array of sulfonyl ynamides can be realized via copper-catalyzed amidative cross-couplings or by elimination of dichloroenamide precursors. Additionally the use of Sonogashira chemistry to further diversify terminal ynamides and the synthesis of solid-supported ynamides was investigated. Electrophilically-activated amides can be reacted with sulfonyl ynamides in order to access highly functionalized 4-aminoquinolines. The straightforward amide activation procedure with triflic anhydride and 2-chloropyridine was found to tolerate a wide range of substrates, which allowed for the development of a library of 4-aminoquinolines with ease. Moreover, 4-aminopyrazoles can be prepared by reacting terminal sulfonyl ynamides with sydnones under copper catalysis. However, as the copper catalysts were also found to promote the degradation of the ynamides, a copper-free strain-promoted alternative was developed. An in situ prepared 3-azacyclohexyne was found to tolerate a wide array of C-4 substituted sydnones, producing a mixture of both the 3,4- and 4,3-fused pyrazoles in good yields. Additional investigations into heterocyclic methodology led to the development of highly sophisticated, non-symmetrical and axially-chiral dibenzo-1,3-diazepines, -oxazepines and -thiazepines from simple, commercially available anilines. The anilines were coupled to their corresponding reaction partners via a chloromethyl intermediate and the 7-membered ring was subsequently formed using direct arylation.
Detail About Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry PDF
- Author : Tim Wezeman
- Publisher : Logos Verlag Berlin GmbH
- Genre : Science
- Total Pages : 253 pages
- ISBN : 383254397X
- Release Date : 31 December 2016
- PDF File Size : 39,7 Mb
- Language : English
- Rating : 4/5 from 21 reviews
Clicking on the GET BOOK button will initiate the downloading process of Sulfonyl Ynamides as Useful Tools for N Heterocyclic Chemistry by Tim Wezeman. This book is available in ePub and PDF format with a single click unlimited downloads.